Postoperative analgesic medications

Oxycodone

Note: always check the prescribing information and your local formulary.

Administration Oral
Starting dose 2 mg for short-acting immediate-release products
5 mg for controlled-release products
Frequency Every 4 hours for short-acting immediate-release products
Every 12 hours for controlled release products
Monitoring Renal function
Comments eGFR < 30 mL/min: risk of accumulation, consider dose reduction.
Provide breakthrough reserve by using short-acting immediate-release oxycodone (1/6 to 1/10 of daily dose).

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