Note: always check the prescribing information and your local formulary.
Administration | Oral, SC, IV |
Starting dose | Oral: 2 mg SC/IV: 1 mg |
Frequency | Oral:
- Every 2–4 hours for short-acting immediate-release products - Every 12 hours for controlled release products SC/IV: Every 2-4 hours. Continuous infusion is not recommended (risk of respiratory depression) |
Monitoring | Renal function |
Comments | Not recommended in patients with renal failure (eGFR < 35 mL/min) Provide breakthrough reserve by using short-acting immediate-release morphine (1/6 to 1/10 of daily dose) |