Brief information on rivaroxaban
- Rivaroxaban
(Xarelto) is an oral direct inhibitor of factor
Xa
- Approved
for
thromboprophylaxis
after elective hip or knee replacement
surgery,
treatment of DVT and
PE,
and
prevention of stroke in
nonvalvular
atrial
fibrillation
- Oral administration
- Prophylactic dose is 10 mg orally once daily.
- Therapeutic dose is 20 mg orally once daily.
- No coagulation monitoring necessary
- There are no specific antidotes against rivaroxaban.
- Elimination half-life of rivaroxaban is 11–13 hours in older adults.