Postoperative analgesic medications

Morphine

Note: always check the prescribing information and your local formulary.
Administration Oral, SC, IV
Starting dose Oral: 2 mg
SC/IV: 1 mg
Frequency Oral:
- Every 2–4 hours for short-acting immediate-release products
- Every 12 hours for controlled release products
SC/IV: Every 2-4 hours. Continuous infusion is not recommended (risk of respiratory depression)
Monitoring Renal function
Comments Not recommended in patients with renal failure (eGFR < 35 mL/min) Provide breakthrough reserve by using short-acting immediate-release morphine (1/6 to 1/10 of daily dose)

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