Treatment failure
Treatment should be changed in the following circumstances:
- Two or more incident fragility fractures
- One incident fracture and an elevated serum β-CTX or P1NP from baseline with no significant reduction during treatment, a significant decrease in BMD, or both
- No significant decrease in either serum β-CTX or P1NP but a significant decrease in BMD
Literature
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Diez-Perez A, Adachi JD, Agnusdei D, et al.
Treatment failure in osteoporosis. Osteoporos Int. 2012 Dec;23(12):2769–2774.