Drowsiness
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Sedation is common and occurs mainly when starting strong opioid treatment or following a dose increase. It is often transient.
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Prolonged sedation may be a sign of overdose or accumulation. Dose reduction must therefore be considered if pain is controlled. Consider opioid rotation (switching opioids) if pain is not controlled.
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Mental confusion and delirium can occur with opioid treatment but the risk is low
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If adverse effects remain uncontrolled despite optimizing treatment, involve a pain specialist